pVXc-​486

Modify Date: 2024-01-15 14:09:55

pVXc-​486 Structure
pVXc-​486 structure
Common Name pVXc-​486
CAS Number 1384984-20-6 Molecular Weight 552.40
Density N/A Boiling Point N/A
Molecular Formula C21H24FN6Na2O6P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of pVXc-​486


pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo[1].

 Names

Name pVXc-​486

 pVXc-​486 Biological Activity

Description pVXc-486 is an orally active and potent phosphate prodrug of VXc-486. pVXc-486 has potent bactericidal activities in vivo[1].
Related Catalog
In Vivo pVXc-486 (oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1]. pVXc-486 (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1]. Animal Model: Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)[1] Dosage: 10, 30, 100 mg/kg Administration: Oral gavage; 5 times per week for 4 weeks Result: Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice.
References

[1]. Locher CP, et al. A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.Antimicrob Agents Chemother. 2015 Mar;59(3):1455-65.

 Chemical & Physical Properties

Molecular Formula C21H24FN6Na2O6P
Molecular Weight 552.40
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