DBCO-NHS ester 3

Modify Date: 2024-01-10 16:31:33

DBCO-NHS ester 3 Structure
DBCO-NHS ester 3 structure
Common Name DBCO-NHS ester 3
CAS Number 1393350-27-0 Molecular Weight 416.43
Density N/A Boiling Point N/A
Molecular Formula C24H20N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DBCO-NHS ester 3


DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

 Names

Name DBCO-NHS ester 3

 DBCO-NHS ester 3 Biological Activity

Description DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].
Related Catalog
References

[1]. Silvie A. Meeuwissen, et al. Copper-free click chemistry on polymersomes: pre- vs. post-self-assembly functionalization. Polymer Chemistry. 2012, 3: 1783-1795.

[2]. Tang F, et al. Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates. Nat Protoc. 2017 Aug;12(8):1702-1721.

 Chemical & Physical Properties

Molecular Formula C24H20N2O5
Molecular Weight 416.43
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