1393350-27-0

1393350-27-0 structure

Name: DBCO-NHS ester 3
Chemical Name: DBCO-NHS ester 3
CAS Number: 1393350-27-0
Molecular Formula: C₂₄H₂₀N₂O₅
Molecular Weight: 416.43
Catalog: Research Areas Cancer
Create Date: 2019-12-09 08:56:19
Modify Date: 2024-01-10 16:31:33
DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

Name	DBCO-NHS ester 3

Description	DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Silvie A. Meeuwissen, et al. Copper-free click chemistry on polymersomes: pre- vs. post-self-assembly functionalization. Polymer Chemistry. 2012, 3: 1783-1795. [2]. Tang F, et al. Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates. Nat Protoc. 2017 Aug;12(8):1702-1721.

Molecular Formula	C₂₄H₂₀N₂O₅
Molecular Weight	416.43