Ghrelin agonist HM01

Modify Date: 2024-01-06 04:37:53

Ghrelin agonist HM01 Structure
Ghrelin agonist HM01 structure
Common Name Ghrelin agonist HM01
CAS Number 1394860-28-6 Molecular Weight 402.36
Density N/A Boiling Point N/A
Molecular Formula C19H29Cl2N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ghrelin agonist HM01


Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM; mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats, also attenuates cachexia in mice bearing bolon-26 (C26) tumors.

 Names

Name Ghrelin agonist HM01

 Ghrelin agonist HM01 Biological Activity

Description Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM; mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats, also attenuates cachexia in mice bearing bolon-26 (C26) tumors.
References References 1. Rudd JA, et al. Front Pharmacol. 2018 Aug 6;9:869. 2. Karasawa H, et al. Neurogastroenterol Motil. 2014 Dec;26(12):1771-82. 3. Villars FO, et al. Int J Mol Sci. 2017 May 5;18(5). pii: E986. View Related Products by Target Ghrelin Receptor (GHSR)

 Chemical & Physical Properties

Molecular Formula C19H29Cl2N3O2
Molecular Weight 402.36
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