1394860-28-6
1394860-28-6 structure
- Name: Ghrelin agonist HM01
- Chemical Name: Ghrelin agonist HM01
- CAS Number: 1394860-28-6
- Molecular Formula: C19H29Cl2N3O2
- Molecular Weight: 402.36
- Create Date: 2020-01-12 09:01:50
- Modify Date: 2024-01-06 04:37:53
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Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM; mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats, also attenuates cachexia in mice bearing bolon-26 (C26) tumors.
| Name | Ghrelin agonist HM01 |
|---|
| Description | Ghrelin agonist HM01 is a novel potent, orally available ghrelin (GHS-R) agonist with Ki of 1.42 nM (human GHS-R1a), induces potent activation of intracellular calcium signaling with EC50 of 1.25 nM; mimics the neuronal effects of ghrelin in the arcuate nucleus and attenuates anorexia-cachexia syndrome in tumor-bearing rats, also attenuates cachexia in mice bearing bolon-26 (C26) tumors. |
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| References | References 1. Rudd JA, et al. Front Pharmacol. 2018 Aug 6;9:869. 2. Karasawa H, et al. Neurogastroenterol Motil. 2014 Dec;26(12):1771-82. 3. Villars FO, et al. Int J Mol Sci. 2017 May 5;18(5). pii: E986. View Related Products by Target Ghrelin Receptor (GHSR) |
| Molecular Formula | C19H29Cl2N3O2 |
|---|---|
| Molecular Weight | 402.36 |