Isodunnianol

Modify Date: 2024-01-14 20:31:52

Isodunnianol Structure
Isodunnianol structure
Common Name Isodunnianol
CAS Number 139726-30-0 Molecular Weight 398.493
Density 1.1±0.1 g/cm3 Boiling Point 511.2±50.0 °C at 760 mmHg
Molecular Formula C27H26O3 Melting Point N/A
MSDS N/A Flash Point 263.0±30.1 °C

 Use of Isodunnianol


Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity[1].

 Names

Name 5,5'-Diallyl-3-(4-allylphenoxy)-2,2'-biphenyldiol
Synonym More Synonyms

 Isodunnianol Biological Activity

Description Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity[1].
Related Catalog
In Vitro Isodunnianol (10 µM; 6, 24 h) 在 H9C2 细胞中诱导自噬并增加 pAMPK172、pULK1555 的表达,降低 pULK1757、SQSTM2 的表达[1]。 Cell Autophagy Assay[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Induced autophagic. Western Blot Analysis[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Significantly increased the expression of pAMPK172, pULK1555,decreased teh expression of pULK1757, SQSTM2 in a time-dependent manner.
References

[1]. Chen C , et al . Isodunnianol alleviates duxorubicin-induced myocardial injury by activating protective autophagy. Food Funct. 2019 May 22;10(5):2651-2657.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 511.2±50.0 °C at 760 mmHg
Molecular Formula C27H26O3
Molecular Weight 398.493
Flash Point 263.0±30.1 °C
Exact Mass 398.188202
PSA 49.69000
LogP 6.74
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.607

 Safety Information

Hazard Codes Xi

 Synonyms

Isodunnianol
12-Hydroxy-drim-8-en-11-saeure-lacton
12-hydroxy-drim-8-en-11-oic acid-lactone
5,5'-Diallyl-3-(4-allylphenoxy)-2,2'-biphenyldiol
Isodrimenin
isoduinnianol
[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-3-[4-(2-propen-1-yl)phenoxy]-
MEGPFBRAROUGQD-NHYWBVRUSA
Isodrimenine
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