CORT 118335
Modify Date: 2024-02-24 09:54:04
CORT 118335 structure
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Common Name | CORT 118335 | ||
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| CAS Number | 1400902-13-7 | Molecular Weight | 428.447 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H23F3N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CORT 118335CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR. |
| Name | 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione |
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| Synonym | More Synonyms |
| Description | CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR. |
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| In Vitro | CORT 118335 (Miricorilant, C118335)?is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR; exhibits in vivo efficacy in the olanzapine-induced weight gain model in rats; can also block GR activity in prostate cancer and slows CRPC progression both in vitro and in vivo. |
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C24H23F3N2O2 |
| Molecular Weight | 428.447 |
| Exact Mass | 428.171173 |
| LogP | 6.21 |
| Index of Refraction | 1.562 |
| 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione |
| 2,4(1H,3H)-Pyrimidinedione, 6-(4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]- |