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1400902-13-7

1400902-13-7 structure
1400902-13-7 structure
  • Name: CORT 118335
  • Chemical Name: 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
  • CAS Number: 1400902-13-7
  • Molecular Formula: C24H23F3N2O2
  • Molecular Weight: 428.447
  • Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
  • Create Date: 2020-01-11 15:58:49
  • Modify Date: 2024-02-24 09:54:04
  • CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR.

Name 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
Synonyms 6-(4-Phenylcyclohexyl)-5-[3-(trifluoromethyl)benzyl]-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-(4-phenylcyclohexyl)-5-[[3-(trifluoromethyl)phenyl]methyl]-
Description CORT 118335 (Miricorilant, C118335) is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR.
In Vitro CORT 118335 (Miricorilant, C118335)?is a novel potent, selective, non-steroidal glucocorticoid receptor (GR) antagonist with Ki of 8 nM, shows modest affinity for MR; exhibits in vivo efficacy in the olanzapine-induced weight gain model in rats; can also block GR activity in prostate cancer and slows CRPC progression both in vitro and in vivo.
Density 1.3±0.1 g/cm3
Molecular Formula C24H23F3N2O2
Molecular Weight 428.447
Exact Mass 428.171173
LogP 6.21
Index of Refraction 1.562