genz-682452

Modify Date: 2024-01-08 10:38:02

genz-682452 Structure
genz-682452 structure
Common Name genz-682452
CAS Number 1401090-53-6 Molecular Weight 389.487
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C20H24FN3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of genz-682452


Ibiglustat (Venglustat) is an inhibitor of glucosylceramide synthase extracted from patent WO 2015089067 A1, compound example 64.

 Names

Name venglustat
Synonym More Synonyms

 genz-682452 Biological Activity

Description Ibiglustat (Venglustat) is an inhibitor of glucosylceramide synthase extracted from patent WO 2015089067 A1, compound example 64.
Related Catalog
In Vivo Ibiglustat is in phase II clinical trials for the treatment of Fabry's disease. Fabry disease, an X-linked disorder of glycosphingolipids that is caused by mutations of the GLA gene that codes for α-galactosidase A, leads to dysfunction of many cell types and includes a systemic vasculopathy[2]. Substrate reduction therapy is an approach that reduces the synthesis of lipids reaching the lysosome through inhibition of glucosylceramide synthase (GCS)[1].
References

[1]. WO 2015089067 A1

[2]. Schiffmann R, et al. Fabry disease. Handb Clin Neurol. 2015;132:231-48.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C20H24FN3O2S
Molecular Weight 389.487
Exact Mass 389.157318
LogP 4.13
Index of Refraction 1.613
Storage condition 2-8℃

 Synonyms

(3S)-1-Azabicyclo[2.2.2]oct-3-yl {2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]-2-propanyl}carbamate
Carbamic acid, N-[1-[2-(4-fluorophenyl)-4-thiazolyl]-1-methylethyl]-, (3S)-1-azabicyclo[2.2.2]oct-3-yl ester
MFCD28502073
venglustat
Ibiglustat
genz-682452
Ansofaxine Hydrochloride
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