AT-IAP
Modify Date: 2024-04-04 18:05:56
AT-IAP structure
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Common Name | AT-IAP | ||
|---|---|---|---|---|
| CAS Number | 1403898-55-4 | Molecular Weight | 509.659 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 678.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C29H40FN5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 364.0±31.5 °C | |
Use of AT-IAPA potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively; exhibits MDA-MB-231 cell proliferation inhibition with IC50 of 4.4 nM; decreases basal and TNF-α-induced cIAP-1 expression in CaP cells, switches TNF-α signaling from pro-survival to pro-apoptotic and increases radiation sensitivity of CaP cells in co-culture with THP-1 cells; shows in vivo efficacy in Balb/c scid mice bearing MDA-MB-231 xenografts. |
| Name | 1-[6-(4-Fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methyl-4-morpholinyl]methyl}-1-piperazinyl]ethanone |
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| Synonym | More Synonyms |
| Description | A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively; exhibits MDA-MB-231 cell proliferation inhibition with IC50 of 4.4 nM; decreases basal and TNF-α-induced cIAP-1 expression in CaP cells, switches TNF-α signaling from pro-survival to pro-apoptotic and increases radiation sensitivity of CaP cells in co-culture with THP-1 cells; shows in vivo efficacy in Balb/c scid mice bearing MDA-MB-231 xenografts. |
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| References | References 1. Tamanini E, et al. J Med Chem. 2017 Jun 8;60(11):4611-4625. 2. Armstrong CW, et al. Oncotarget. 2016 Feb 16;7(7):7885-98. View Related Products by Target IAP |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 678.3±55.0 °C at 760 mmHg |
| Molecular Formula | C29H40FN5O2 |
| Molecular Weight | 509.659 |
| Flash Point | 364.0±31.5 °C |
| Exact Mass | 509.316589 |
| LogP | 4.23 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.549 |
| Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]- |
| 1-[6-(4-Fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methyl-4-morpholinyl]methyl}-1-piperazinyl]ethanone |