u-Conotoxin GIIIB

Modify Date: 2024-01-06 21:42:45

u-Conotoxin GIIIB structure	Common Name	u-Conotoxin GIIIB
	CAS Number	140678-12-2	Molecular Weight	2640.17
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₀₁H₁₇₅N₃₉O₃₀S₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of u-Conotoxin GIIIB

μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a NaV1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction[1][2][3].

Name	μ-CONOTOXIN GIIIB
Synonym	More Synonyms

Description	μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a NaV1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	NaV1.4 Channel[2]
References	[1]. orres NS. Activation of reverse Na+-Ca2+ exchanger by skeletal Na+ channel isoform increases excitation-contraction coupling efficiency in rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol. 2021 Feb 1;320(2):H593-H603. [2]. Garcia N, et al. Involvement of the Voltage-Gated Calcium Channels L- P/Q- and N-Types in Synapse Elimination During Neuromuscular Junction Development. Mol Neurobiol. 2022 Jul;59(7):4044-4064. [3]. Hill JM, et al. Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels. Biochemistry. 1996 Jul 9;35(27):8824-35.

Molecular Formula	C₁₀₁H₁₇₅N₃₉O₃₀S₇
Molecular Weight	2640.17
Exact Mass	2638.14000
PSA	1338.14000

Safety Phrases	22-24/25
RIDADR	UN 3462 6
Packaging Group	III
Hazard Class	6.1(b)

Conotoxin GIIIB

U-conotoxin giiib

ARG-ASP-CYS-CYS-THR-HYP-HYP-ARG-LYS-CYS-LYS-ASP-ARG-GLN-CYS-LYS-HYP-GLN-ARG-CYS-CYS-ALA-NH2

mhu-conotoxin GIIIB

GEOGRAPHUTOXIN II

GTXII

M-CONOTOXIN GIIIB

u-Conotoxin GIIIB

Use of u-Conotoxin GIIIB

Names

u-Conotoxin GIIIB Biological Activity

Chemical & Physical Properties

Safety Information

Synonyms