VU0364770 hydrochloride
Modify Date: 2024-01-10 18:43:02
VU0364770 hydrochloride structure
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Common Name | VU0364770 hydrochloride | ||
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| CAS Number | 1414842-70-8 | Molecular Weight | 269.13 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H10Cl2N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of VU0364770 hydrochlorideVU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1]. |
| Name | VU0364770 hydrochloride |
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| Description | VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1]. |
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| Related Catalog | |
| Target |
Rat mGlu4:290 nM (EC50) Human mGlu4:1.1 μM (EC50) mGlu6:6.8 μM (EC50) mGlu5:17.9 μM (EC50) |
| References |
| Molecular Formula | C12H10Cl2N2O |
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| Molecular Weight | 269.13 |