Niclosamide olamine

Modify Date: 2024-01-04 20:35:59

Niclosamide olamine structure	Common Name	Niclosamide olamine
	CAS Number	1420-04-8	Molecular Weight	386.230
	Density	N/A	Boiling Point	155-156 °C
	Molecular Formula	C₁₅H₁₅Cl₂N₃O₅	Melting Point	91-93 °C(lit.)
	MSDS	N/A	Flash Point	149 °F

Use of Niclosamide olamine

Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.

Name	niclosamide-olamine
Synonym	More Synonyms

Description	Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Autophagy >> Autophagy

Boiling Point	155-156 °C
Melting Point	91-93 °C(lit.)
Molecular Formula	C₁₅H₁₅Cl₂N₃O₅
Molecular Weight	386.230
Flash Point	149 °F
Exact Mass	385.059601
PSA	141.40000
LogP	4.09340
Stability	Stable. Hydrolyzes in concentrated acidic or basic solutions.
Water Solubility	soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VN8575000

CAS REGISTRY NUMBER :: 1420-04-8

LAST UPDATED :: 199607

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H8-Cl2-N2-O4.C2-H7-N-O

MOLECULAR WEIGHT :: 388.23

WISWESSER LINE NOTATION :: WNR CG DMVR BQ EG &Z2Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,103,1976/1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,126,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 336600 ug/kg

SEX/DURATION :: female 5-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 53,1,1995 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

Safety Phrases	S16-S26-S36/37/39-S45
RIDADR	UN 1325 4.1/PG 2
WGK Germany	3
Packaging Group	III
Hazard Class	4.1

Luomiecide

Hl 2448

MFCD01941566

EINECS 215-811-7

Mollutox

2',5-dichloro-4'-nitrosalicylanilide

5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide - 1-propanamine (1:1)

Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with 1-propanamine (1:1)

clonitralid

Niclosamide ethanolamine salt

2’,5-dichloro-4’-nitrosalicylanilide - 2-aminoethanol (1:1)

BAYER73

(2-hydroxyethyl)ammonium 4-chloro-2-[(2-chloro-4-nitroanilino)carbonyl]phenolate

BAY-73

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide—2-aminoethan-1-ol

Snanilcide

BAYER-6076

Clonitralide

NICLOSAMIDEL

5,2'-dichloro-4'-nitro-salicylanilide ethanolamine salt

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Niclosamide olamine
Price: Click To Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Niclosamide olamine
Price: ￥346.0/500g ￥116.0/100g ￥656.0/1kg ￥66.0/25g
Purity: 97.0%
Delivery: 1 Day
Contact: Liu jia
Email: 2130147988@qq.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Niclosamide-olamine
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: Niclosamide-olamine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Niclosamide ethanolamine salt
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Niclosamide ethanolamine salt
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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