S-Acetoacetylcoenzyme a structure
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Common Name | S-Acetoacetylcoenzyme a | ||
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CAS Number | 1420-36-6 | Molecular Weight | 851.61 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C25H40N7O18P3S | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of S-Acetoacetylcoenzyme aAcetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids[1][2][3]. |
Name | acetoacetyl-CoA |
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Synonym | More Synonyms |
Description | Acetoacetyl CoA is the precursor of HMG-CoA in the mevalonate pathway. Acetoacetyl-CoA thiolase catalyzes the reaction to form acetoacetyl-CoA from two acetyl-CoA molecules. Acetoacetyl CoA is essential for cholesterol biosynthesis. Acetoacetyl-CoA is also a intermediate in the biological breakdown and synthesis of fatty acids[1][2][3]. |
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Related Catalog | |
Target |
Human Endogenous Metabolite |
In Vitro | The purified recombinant Msed_0389 and Msed_1423 catalyze the NAD-dependent oxidation of (S)-3-hydroxybutyryl-CoA to Acetoacetyl-CoA and are highly specific for their substrate (Km of 2.6 μM and 5 μM, respectively)[2]. The homologous bifunctional protein is the only enzyme capable to covert crotonyl-CoA into Acetoacetyl-CoA in autotrophic Desulfurococcales (Ignicoccus hospitalis) and Thermoproteales (Pyrobaculum neutrophilus) that use the dicarboxylate/4-hydroxybutyrate cycle for CO2 fixation[2]. |
References |
Molecular Formula | C25H40N7O18P3S |
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Molecular Weight | 851.61 |
Exact Mass | 851.13600 |
PSA | 435.43000 |
LogP | 0.00680 |
Storage condition | 20°C |
Precursor 0 | |
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DownStream 2 | |
S-Acetoacetylcoenzyme a |