Acetyl-CoA

Modify Date: 2024-01-01 18:03:44

Acetyl-CoA structure	Common Name	Acetyl-CoA
	CAS Number	72-89-9	Molecular Weight	809.571
	Density	1.9±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₈N₇O₁₇P₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Acetyl-CoA

Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis[1][2][3][4].

Name	acetyl-CoA
Synonym	More Synonyms

Description	Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis[1][2][3][4].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	Acetyl coenzyme A 在饥饿的 U2OS 细胞中增加细胞质蛋白乙酰化，同时减少饥饿诱导的自噬通量。(U2OS 细胞稳定表达 GFP-LC3 并显微注射Acetyl coenzyme A; 在无营养条件下，用 100 nM BafA1 孵育 3 h 后固定)[2]。
In Vivo	Acetyl coenzyme A 通过抑制适应不良的自噬来抑制压力超负荷诱导的小鼠心肌病[2][3]。被剥夺食物 (但可以随意饮水) 24 小时的小鼠在几个器官 (包括心脏和肌肉) 中表现出总 Acetyl coenzyme A 水平显着降低，对应于蛋白质乙酰化水平的降低。相同的实验条件对大脑中 Acetyl coenzyme A 的浓度没有重大影响，实际上会增加肝脏 Acetyl coenzyme A 和蛋白质乙酰化水平[4]。
References	[1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50. [2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25. [3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93. [4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

Density	1.9±0.1 g/cm3
Molecular Formula	C₂₃H₃₈N₇O₁₇P₃S
Molecular Weight	809.571
Exact Mass	809.125793
PSA	425.34000
LogP	-3.89
Index of Refraction	1.718

Ethanoic anhydride

CAS#:108-24-7

Coenzyme A

CAS#:85-61-0

Acetyl-CoA

CAS#:72-89-9

Literature: Journal of the American Chemical Society, , vol. 75, p. 2520 Journal of Biological Chemistry, , vol. 203, p. 869,872, 877

ch3cho

CAS#:75-07-0

Acetyl-CoA

CAS#:72-89-9

Literature: US2013/66035 A1, ; Page/Page column ;

Coenzyme A

CAS#:85-61-0

Acetyl-CoA

CAS#:72-89-9

Literature: Biochemische Zeitschrift, , vol. 329, p. 175 Journal of Biological Chemistry, , vol. 199, p. 65,66

1-acetylimidazole

CAS#:2466-76-4

Coenzyme A

CAS#:85-61-0

Acetyl-CoA

CAS#:72-89-9

Literature: Bioscience, biotechnology, and biochemistry, , vol. 67, # 10 p. 2106 - 2114

SODIUM THIOLACETATE

CAS#:34832-35-4

Coenzyme A

CAS#:85-61-0

Acetyl-CoA

CAS#:72-89-9

Literature: Journal of the American Chemical Society, , vol. 74, p. 3205

Sodium 2-oxopro...

CAS#:113-24-6

Coenzyme A

CAS#:85-61-0

Acetyl-CoA

CAS#:72-89-9

Literature: Biochemistry, , vol. 51, # 13 p. 2795 - 2803

S-Acetoacetylco...

CAS#:1420-36-6

Acetyl-CoA

CAS#:72-89-9

Literature: Organic Letters, , vol. 9, # 20 p. 3877 - 3880

ch3cho

CAS#:75-07-0

Coenzyme A

CAS#:85-61-0

Acetyl-CoA

CAS#:72-89-9

Literature: Biochemistry, , vol. 50, # 39 p. 8407 - 8416

acetic acid

CAS#:64-19-7

succinyl-CoA

CAS#:604-98-8

Acetyl-CoA

CAS#:72-89-9

Literature: Biochemistry, , vol. 51, # 42 p. 8422 - 8434

Precursor 9
CAS#:108-24-7 Ethanoic anhydride CAS#:85-61-0 Coenzyme A CAS#:75-07-0 ch3cho CAS#:2466-76-4 1-acetylimidazole
CAS#:34832-35-4 SODIUM THIOLACETATE CAS#:113-24-6 Sodium 2-oxopro... CAS#:1420-36-6 S-Acetoacetylco... CAS#:64-19-7 acetic acid
CAS#:604-98-8 succinyl-CoA
DownStream 9
CAS#:480-64-8 o-Orsellinic acid CAS#:543-24-8 Ac-Gly-OH CAS#:85-61-0 Coenzyme A CAS#:5147-00-2 O-acetyl-L-serine
CAS#:2140-48-9 butyryl-CoA CAS#:140-11-4 Benzyl acetate CAS#:26157-58-4 2-acetamidoethy... CAS#:1420-36-6 S-Acetoacetylco...
CAS#:27548-93-2 Baccatin III

acetylocholine

Azetylcholin

ac-CoA

Choline acetate

S-{(9R)-1-[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3λ,5λ-diphosphaheptadecan-17-yl} ethanethioate (non-preferred name)

Acetyl-CoenzymeA

S-ACETYL COENZYME A

acetyl CoA

Acetyl-CoA,Tri-Na

O-Acetylcholine

S-acetylcoenzyme A

[3H]-Acetylcholine

Acetyl choline ion

[14C]-Acetyl-Coenzyme A

S-{(9R)-1-[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3λ,5λ-diphosphaheptadecan-17-yl} ethanethioate (non-preferred name)

Adenosine, 5'-O-[[[[(3R)-4-[[3-[[2-(acetylthio)ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate)

Coenzyme A S-Acetate

Choline acetate (ester)

trilithium,[2-[[[[4-[[3-(2-acetylsulfanylethylamino)-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]-oxidophosphoryl]oxy-oxidophosphoryl]oxymethyl]-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-3-yl] hydrogen phosphate,trihydrate

Acetyl coenzyme A

coenzyme A, acetyl-

ac-S-CoA

[3H]-Acetyl-Coenzyme A

(2-Acetoxyethyl)trimethylammonium

Ach

acetyl-S-CoA

Acetylcholinum

acetylCoA

Acetyl-Coenzyme A

[14C]-Acetylcholine

Coenzyme A, S-acetate

acetylcholine

acetylcholine cation

Acetyl-CoA

Use of Acetyl-CoA

Names

Acetyl-CoA Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms