Baccatin III

Modify Date: 2024-01-06 18:02:41

Baccatin III Structure
Baccatin III structure
Common Name Baccatin III
CAS Number 27548-93-2 Molecular Weight 586.627
Density 1.4±0.1 g/cm3 Boiling Point 713.6±60.0 °C at 760 mmHg
Molecular Formula C31H38O11 Melting Point 229-234 °C
MSDS N/A Flash Point 226.9±26.4 °C

 Use of Baccatin III


Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs[1].

 Names

Name Baccatine III
Synonym More Synonyms

 Baccatin III Biological Activity

Description Baccatin III is a natural product isolated from Pacific yew tree and related species. Baccatin III reduces tumor progression by inhibiting the accumulation and suppressive function of MDSCs[1].
Related Catalog
References

[1]. Lee YH, et al. Baccatin III, a precursor for the semisynthesis of paclitaxel, inhibits the accumulation and suppressive activity of myeloid-derived suppressor cells in tumor-bearing mice. Int Immunopharmacol. 2014 Aug;21(2):487-93.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 713.6±60.0 °C at 760 mmHg
Melting Point 229-234 °C
Molecular Formula C31H38O11
Molecular Weight 586.627
Flash Point 226.9±26.4 °C
Exact Mass 586.241394
PSA 165.89000
LogP 4.06
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.605
Storage condition 2-8°C
Stability 4 Year Shelf Life

 Safety Information

Hazard Codes T: Toxic;
Risk Phrases R45
Safety Phrases 53-22-26-36/37/39-45-24/25
RIDADR 1544
WGK Germany 3
Packaging Group III
Hazard Class 6.1(b)

 Synthetic Route

 Synonyms

Baccatin III
MFCD00153921
(2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
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