10-Deacetylbaccatin III

Modify Date: 2024-01-02 10:11:07

10-Deacetylbaccatin III structure	Common Name	10-Deacetylbaccatin III
	CAS Number	32981-86-5	Molecular Weight	544.590
	Density	1.4±0.1 g/cm3	Boiling Point	716.8±60.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₆O₁₀	Melting Point	231-236 °C
	MSDS	Chinese USA	Flash Point	233.5±26.4 °C

Use of 10-Deacetylbaccatin III

10-Deacetylbaccatin-III is an intermediate for taxol analog preparations. IC50 value:Target: Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III. 10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated. 10-Deacetylbaccine III is an antineoplastic agent and an anti-cancer intermediate.

Name	10-deacetylbaccatin III
Synonym	More Synonyms

Description	10-Deacetylbaccatin-III is an intermediate for taxol analog preparations. IC50 value:Target: Taxols have exhibit antitumor agents. Several of these taxols can be synthesized from 10- Deacetylbaccatin-III. 10-Deacetylbaccine III is the fifth intermediate of paclitaxel biosynthesis. The biosynthetic pathway consists of approximately 20 enzymatic steps but is not fully elucidated. 10-Deacetylbaccine III is an antineoplastic agent and an anti-cancer intermediate.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
References	[1]. Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg). 2013 Jan;15(1):19-26. [2]. Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56. [3]. Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26(4):552-6. [4]. Kevin Walker and Rodney Croteau. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. PNAS, 2000 , 97（25）：13591-13596.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

References

[1]. Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg). 2013 Jan;15(1):19-26.

[2]. Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56.

[3]. Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26(4):552-6.

[4]. Kevin Walker and Rodney Croteau. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. PNAS, 2000 , 97（25）：13591-13596.

Density	1.4±0.1 g/cm3
Boiling Point	716.8±60.0 °C at 760 mmHg
Melting Point	231-236 °C
Molecular Formula	C₂₉H₃₆O₁₀
Molecular Weight	544.590
Flash Point	233.5±26.4 °C
Exact Mass	544.230835
PSA	159.82000
LogP	3.51
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.624
Water Solubility	INSOLUBLE

10-Deacetylbaccatin III MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T:Toxic
Risk Phrases	R23/24/25
Safety Phrases	S45-S38-S36/37/39-S28A
RIDADR	1544
WGK Germany	3
Packaging Group	III
Hazard Class	6.1(b)

Precursor 7
CAS#:115437-18-8 7-O-(Triethylsi... CAS#:32981-90-1 ACETYLBACCATIN ... CAS#:27548-93-2 Baccatin III CAS#:33069-62-4 Paclitaxel
CAS#:78432-77-6 Deacetyltaxol CAS#:187960-83-4 (3aS,5S,7aS,10a... CAS#:187960-85-6 2-((3aS,5S,8S,9...
DownStream 10
CAS#:143527-73-5 13-{[(3-t-Boc)-... CAS#:183133-94-0 7,10-dimethoxy-... CAS#:33069-62-4 Paclitaxel CAS#:27548-93-2 Baccatin III
CAS#:115437-18-8 7-O-(Triethylsi... CAS#:125354-16-7 Docetaxal CAS#:133524-70-6 3'-N-debenzoyltaxol CAS#:149107-84-6 7,10-Bis[O-(tri...
CAS#:183133-96-2 cabazitaxel CAS#:156294-36-9 Larotaxel

Disposition of [G-(3)H]paclitaxel and cremophor EL in a patient with severely impaired renal function.

Drug Metab. Dispos. 27 , 1300, (1999)

In the present work, we studied the pharmacokinetics and metabolic disposition of [G-(3)H]paclitaxel in a female patient with recurrent ovarian cancer and severe renal impairment (creatinine clearance...

Molecular mechanisms of patupilone resistance.

Cancer Res. 68 , 10197-10204, (2008)

Patupilone is an epothilone in advanced clinical development that has shown promising efficacy in heavily pretreated patients. This study aimed at characterizing the mechanisms of patupilone activity ...

Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli Kevin Walker and Rodney Croteau PNAS

Proc. 10th Am. Peptide Symp 97 , 13591-13596, (2000)

10-Dab

10-DAB (10-Deacetylbaccatin)

MFCD00132913

EINECS 418-680-6

(2α,5β,7β,10α,13α)-4-Acetoxy-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

(2α,5β,7β,10β,13α)-4-(acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate

10-Deacetylbaccatine

10-deacetylbaccatin11

10-DAB-III

10DBA III

10-Deacetyl

10-DEACETYLBACCATIN

10-Deacetylbaccatin-III

10-desacetylbaccatin III

10-Deacetylbaccatin III

DESACETYLBACCATINE

Docetaxel impurity E

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6S,9S,11S,12S,12aR,12bS)-

(2α,5β,7β,10β,13α)-4-Acetoxy-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate