179343-23-8

179343-23-8 structure

Name: Acetyl-CoA Carboxylase-IN-1
Chemical Name: 6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
CAS Number: 179343-23-8
Molecular Formula: C₁₃H₉Br₂N₅
Molecular Weight: 395.05200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-11-28 16:03:40
Modify Date: 2024-01-12 15:14:12
Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1].

Name	6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
Synonyms	6-arylpyrido[2,3-d]pyrimidine deriv. 18 QC-198 6-(2,6-dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine 2v58

Description	Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC50 value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; 大肠杆菌) 具有抗菌活性，对于 WT、WT+ PMBN、ΔacrAB、ΔacrAB+PMBN、ΔtolC 和 ΔtolC+ PMBN 的 MIC 值分别为 >25、3.13、25、0.39、1.56 和 0.1 μM[1]。
References	[1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525.

HS Code	2933990090

20781-06-0

67197-53-9

~63%

179343-23-8

Precursor 2
20781-06-0 67197-53-9
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%