70205-50-4

70205-50-4 structure

Name: Pyruvate Carboxylase-IN-1
Chemical Name: Pyruvate Carboxylase-IN-1
CAS Number: 70205-50-4
Molecular Formula: C₁₅H₁₄O₃
Molecular Weight: 242.27
Create Date: 2022-05-20 08:42:51
Modify Date: 2024-01-12 20:45:01
Pyruvate Carboxylase-IN-1 (compound 37) is a potent inhibitor of pyruvate carboxylase (PC) with IC50s of 0.204 and 0.104 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-1 is a natural analog of erianin. Pyruvate Carboxylase-IN-1 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC)[1].

Name	Pyruvate Carboxylase-IN-1

Description	Pyruvate Carboxylase-IN-1 (compound 37) is a potent inhibitor of pyruvate carboxylase (PC) with IC50s of 0.204 and 0.104 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-1 is a natural analog of erianin. Pyruvate Carboxylase-IN-1 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Sheng Y, et al. Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming. J Med Chem. 2022;65(1):460-484.

Molecular Formula	C₁₅H₁₄O₃
Molecular Weight	242.27