950736-05-7

950736-05-7 structure

Name: B-Raf IN 1
Chemical Name: Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)
CAS Number: 950736-05-7
Molecular Formula: C₂₉H₂₄F₃N₅O
Molecular Weight: 515.529
Catalog: Research Areas Cancer
Create Date: 2018-02-11 08:00:00
Modify Date: 2024-01-05 11:29:22
B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.

Name	Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)
Synonyms	N-[3-(3-{4-[(Dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)- B-Raf IN 1

Description	B-Raf IN 1 is a potent and selective B-Raf kinase inhibitor with an IC50 of 24 nM.
Related Catalog	Research Areas >> Cancer
Target	B-Raf:24 nM (IC50)
In Vitro	B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0.92 and 0.78 μM, respectively[1].
References	[1]. Berger DM, et al. Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.