2648698-30-8

2648698-30-8 structure

Name: B-Raf IN 5
Chemical Name: B-Raf IN 5
CAS Number: 2648698-30-8
Molecular Formula: C₂₃H₁₈ClF₃N₆O₃S₂
Molecular Weight: 583.01
Catalog: Signaling Pathways MAPK/ERK Pathway Raf
Create Date: 2022-04-06 13:02:01
Modify Date: 2024-01-12 17:56:05
B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].

Name	B-Raf IN 5

Description	B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> Raf
References	[1]. Schneider M, et al. Structure-Based and Knowledge-Informed Design of B-Raf Inhibitors Devoid of Deleterious PXR Binding. J Med Chem. 2022;65(2):1552-1566.

Molecular Formula	C₂₃H₁₈ClF₃N₆O₃S₂
Molecular Weight	583.01