Antimalarial compound 49c
Modify Date: 2024-02-19 10:48:44
Antimalarial compound 49c structure
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Common Name | Antimalarial compound 49c | ||
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| CAS Number | 1422207-75-7 | Molecular Weight | 514.67 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H38N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Antimalarial compound 49cAntimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM; blocks invasion and egress of P. falciparum without impacting intraerythrocytic growth, specifically inhibits recombinant PfPMIX and PfPMX (r-PMIXFlag and r-PMXFlag), recapitulating the defect in invasion and egress of P. falciparum in the erythrocytic blood stages; also interferes with invasion and egress in T. gondii by targeting TgASP3 |
| Name | Antimalarial compound 49c |
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| Description | Antimalarial compound 49c is a potent antimalarial peptidomimetic inhibitor originally developed against Plasmepsin II selectively targets TgASP3, PfPMIX, and PfPMX, shows very potent antimalarial effects only after 72 h of treatment with IC50 of 0.6 nM; blocks invasion and egress of P. falciparum without impacting intraerythrocytic growth, specifically inhibits recombinant PfPMIX and PfPMX (r-PMIXFlag and r-PMXFlag), recapitulating the defect in invasion and egress of P. falciparum in the erythrocytic blood stages; also interferes with invasion and egress in T. gondii by targeting TgASP3 |
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| References | References 1. Ciana C, et al. Bioorg Med Chem Lett. 2013 Feb 1;23(3):658-62. 2. Mukherjee B, et al. EMBO J. 2018 Apr 3;37(7). pii: e98047. 3. Pino P, et al. Science. 2017 Oct 27;358(6362):522-528. 4. Dogga SK, et al. Elife. 2017 Sep 12;6. pii: e27480. View Related Products by Target Parasite |
| Molecular Formula | C31H38N4O3 |
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| Molecular Weight | 514.67 |