BI-9627 hydrochloride
Modify Date: 2024-01-10 21:28:40
BI-9627 hydrochloride structure
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Common Name | BI-9627 hydrochloride | ||
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| CAS Number | 1422252-46-7 | Molecular Weight | 392.80 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H20ClF3N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BI-9627 hydrochlorideBI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury. |
| Name | BI-9627 hydrochloride |
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| Description | BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (drug-drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury. |
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| Molecular Formula | C16H20ClF3N4O2 |
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| Molecular Weight | 392.80 |