L 701324

Modify Date: 2024-01-05 23:18:20

L 701324 Structure
L 701324 structure
Common Name L 701324
CAS Number 142326-59-8 Molecular Weight 363.794
Density 1.4±0.1 g/cm3 Boiling Point 584.7±50.0 °C at 760 mmHg
Molecular Formula C21H14ClNO3 Melting Point N/A
MSDS Chinese USA Flash Point 307.4±30.1 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of L 701324


L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.).

 Names

Name 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-1H-quinolin-2-one
Synonym More Synonyms

 L 701324 Biological Activity

Description L-701324 is an orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.Target: NMDA ReceptorL-701324 is a potent, active anticonvulsant with a reduced propensity to activate mesolimbic dopaminergic systems in rodents. L-701324 exhibits a beneficial action in the animal model of parkinsonian rigidity, but not that of parkinsonian akinesia. L-701324 (2.5-40 mg/kg, i.p.) dose-dependently decreased the muscle tone enhanced by haloperidol (1-5 mg/kg, i.p.).
Related Catalog
References

[1]. Piotr Wlaz, et al. Differential effects of glycine on the anticonvulsant activity of D-cycloserine and L-701,324 in mice. Pharmacological Reports 2011,63,1231-1234

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 584.7±50.0 °C at 760 mmHg
Molecular Formula C21H14ClNO3
Molecular Weight 363.794
Flash Point 307.4±30.1 °C
Exact Mass 363.066223
PSA 62.32000
LogP 5.50
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.680
Storage condition 2-8℃

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport

 Articles26

More Articles
NMDA/glutamate mechanism of magnesium-induced anxiolytic-like behavior in mice.

Pharmacol. Rep. 60(5) , 655-63, (2008)

The anxiolytic-like activity of magnesium in mice during the elevated plus maze (EPM) has been demonstrated previously. In the present study, we examined the involvement of NMDA/glutamate receptor lig...

NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice.

Pharmacol. Biochem. Behav. 88(2) , 158-64, (2007)

Antidepressant-like activity of magnesium in forced swim test (FST) was demonstrated previously. Also, enhancement of such activity by joint administration of magnesium and antidepressants was shown. ...

Activation of the NMDA/glutamate receptor complex antagonizes the NMDA antagonist-induced antidepressant-like effects in the forced swim test.

Pharmacol. Rep. 59(5) , 595-600, (2007)

The antidepressant activity of NMDA receptor antagonists has been demonstrated, and their mechanism of action was based on the assumption of their selectivity for the NMDA receptor only. However, no d...

 Synonyms

7-chloro-3-(3-phenoxyphenyl)quinoline-2,4-diol
Sulprostone
2(1H)-Quinolinone, 7-chloro-4-hydroxy-3-(3-phenoxyphenyl)-
2,4-quinolinediol, 7-chloro-3-(3-phenoxyphenyl)-
7-Chloro-4-hydroxy-3-(3-phenoxyphenyl)-2(1H)-quinolinone
7-Chloro-4-hydroxy-3-(3-phenoxyphenyl)quinolin-2(1H)-one
L-701,324
L-701324
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