Lats-IN-1
Modify Date: 2024-08-10 00:05:44
Lats-IN-1 structure
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Common Name | Lats-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 1424635-83-5 | Molecular Weight | 334.39 | |
| Density | 1.36±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H14N4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Lats-IN-1Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1]. |
| Name | Lats-IN-1 |
|---|---|
| Synonym | More Synonyms |
| Description | Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1]. |
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| Related Catalog | |
| In Vitro | The IC50 for Lats-IN-1 increases with the ATP concentration[1]. Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM[1]. Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids[1]. Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation[1]. Cell Proliferation Assay[1] Cell Line: MCF 10A cells Concentration: 10 μM Incubation Time: 24 hours Result: Decreased the phosphorylation of Yap at residue S127. |
| References |
| Density | 1.36±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H14N4OS |
| Molecular Weight | 334.39 |
| Hazard Codes | Xi |
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| MFCD33402276 |
| 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, N-[3-(phenylmethyl)-2(3H)-thiazolylidene]- |