Azt-pmap

Modify Date: 2024-01-09 09:52:56

Azt-pmap Structure
Azt-pmap structure
 Common Name Azt-pmap
CAS Number 142629-81-0 Molecular Weight 508.42200
Density N/A Boiling Point N/A
Molecular Formula C20H25N6O8P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Azt-pmap


Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity[1]. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection[2].

 Names

Name So221
Synonym More Synonyms

 Azt-pmap Biological Activity

Description Azt-pmap, a nucleoside analogue, is an aryl phosphate derivative of AZT. Azt-pmap shows anti-HIV activity[1]. AZT is a nucleoside reverse transcriptase inhibitor (NRTI) for HIV infection[2].
Related Catalog
Target

HIV-1

In Vitro Azt-pmap shows anti-HIV-1 activities in infected C8166 and JM cells with EC50s of 0.08 and0.32 μM, respectively. Azt-pmap displays toxicities in infected C8166 and JM cells with TC50s of 500 μM, respectively. Azt-pmap inhibits virus replication[1].
References

[1]. McGuigan C, et al. Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT. Antiviral Res. 1992 Apr;17(4):311-21.

[2]. Gray LR, et al. The NRTIs lamivudine, stavudine and zidovudine have reduced HIV-1 inhibitory activity in astrocytes. PLoS One. 2013 Apr 16;8(4):e62196.

 Chemical & Physical Properties

Molecular Formula C20H25N6O8P
Molecular Weight 508.42200
Exact Mass 508.14700
PSA 197.51000
LogP 2.00986

 Synonyms

(S)-2-{[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-phenoxy-phosphorylamino}-propionic acid methyl ester
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Chemsrc provides Azt-pmap(CAS#:142629-81-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Azt-pmap are included as well.>> amp version: Azt-pmap

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