FAK inhibitor 5

Modify Date: 2024-01-12 07:14:37

FAK inhibitor 5 structure	Common Name	FAK inhibitor 5
	CAS Number	1426683-30-8	Molecular Weight	367.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₁N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FAK inhibitor 5

FAK inhibitor 5 (compound 2) is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range[1].

Name	FAK inhibitor 5

Description	FAK inhibitor 5 (compound 2) is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK
Target	1.6 μM (pre-incubation 5 min ATP 0.5 μM), 1.3 μM (pre-incubation 60 min ATP 0.5 μM), 3.0 μM (pre-incubation 5 min ATP 1000 μM), 1.0 μM (pre-incubation 60 min ATP 1000 μM).
In Vitro	The binding interactions between FAK inhibitor 5 (compound 2) in the FAK allosteric site is mostly hydrophobic in nature. Exposure of the allosteric pocket by the dramatic movement of Ile547 is accompanied by an equally significant movement of Arg550 in toward the allosteric binding site, where it packs along the tricyclic core of compounds 2. Notably, the terminal ethylphenyl group of compounds 2 occupies the DFG-in pocket, thereby dislodging Phe565 and enabling the structural rearrangement of the activation loop and observed occlusion of the FAK active site[1].
References	[1]. Iwatani M, et al. Discovery and characterization of novel allosteric FAK inhibitors. Eur J Med Chem. 2013 Mar;61:49-60.

Molecular Formula	C₂₀H₂₁N₃O₂S
Molecular Weight	367.46

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FAK inhibitor 5
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Purity: 98.0%
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