hGGPPS-IN-1

Modify Date: 2024-01-08 10:57:14

hGGPPS-IN-1 Structure
hGGPPS-IN-1 structure
Common Name hGGPPS-IN-1
CAS Number 1429012-38-3 Molecular Weight 401.27
Density N/A Boiling Point N/A
Molecular Formula C13H13N3O6P2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of hGGPPS-IN-1


hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].

 Names

Name hGGPPS-IN-1

 hGGPPS-IN-1 Biological Activity

Description hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo[1].
Related Catalog
References

[1]. Lee HF, et al. Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase. J Med Chem. 2022;65(3):2471-2496.

 Chemical & Physical Properties

Molecular Formula C13H13N3O6P2S
Molecular Weight 401.27