AKT-IN-6
Modify Date: 2024-01-12 10:52:45
AKT-IN-6 structure
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Common Name | AKT-IN-6 | ||
|---|---|---|---|---|
| CAS Number | 1430056-54-4 | Molecular Weight | 389.426 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 662.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C22H20FN5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 354.5±31.5 °C | |
Use of AKT-IN-6AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). |
| Name | INCB-047775 |
|---|---|
| Synonym | More Synonyms |
| Description | AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1). |
|---|---|
| Related Catalog | |
| Target |
Akt1 Akt2 Akt3 |
| In Vitro | Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2]. |
| References |
[2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274. |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 662.5±55.0 °C at 760 mmHg |
| Molecular Formula | C22H20FN5O |
| Molecular Weight | 389.426 |
| Flash Point | 354.5±31.5 °C |
| Exact Mass | 389.165192 |
| LogP | 1.38 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.671 |
| Storage condition | store at -20℃ for one year（Powder） |
| 5-{2-[(2S)-1-Amino-3-(3-fluorophenyl)-2-propanyl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}-1-methyl-1H-pyrazole-4-carbonitrile |
| MFCD30470660 |
| 1H-Pyrazole-4-carbonitrile, 5-[2-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-methyl- |