Bryostatin 3
Modify Date: 2024-01-03 19:08:03
Bryostatin 3 structure
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Common Name | Bryostatin 3 | ||
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| CAS Number | 143370-84-7 | Molecular Weight | 888.99 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 993.2±65.0 °C at 760 mmHg | |
| Molecular Formula | C46H64O17 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 286.2±27.8 °C | |
Use of Bryostatin 3Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2]. |
| Name | (1S,3Z,5R,7Z,9S,11S,13S,15R,17R,21R,23R,24S,29S)-13-Acetoxy-1,11,17-trihydroxy-21-[(1R)-1-hydroxyethyl]-7-(2-methoxy-2-oxoethylidene)-2,2,12,12-tetramethyl-19,26-dioxo-20,25,30,31,32-pentaoxapentacyclo[21.6.1.15,9.111,15.024,28]dotriaconta-3,27-dien-29-yl (2E,4E)-2,4-octadienoate |
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| Synonym | More Synonyms |
| Description | Bryostatin 3, a macrocyclic lactone, is a protein kinase C activator, with a Ki of 2.75 nM. Bryostatin 3 can block 12-O-tetradecanoylphorbol-13-acetate (TPA) inhibition of cell proliferation, yet did not block TPA-enhanced cell-substratum adhesion[1][2]. |
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| Related Catalog | |
| Target |
Ki: 2.75 nM (protein kinase C)[1] |
| In Vitro | Bryostatin 3 (1 μM; 24 h) does not inhibit [3Hlthymidine incorporation and largely blocks the growth-inhibitory action of TPA[2]. Bryostatin 3 (1 μM; 24 h) blocks the action of TPA to inhibit cell proliferation but does not block TPA-enhanced cell-substratum adhesion[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 993.2±65.0 °C at 760 mmHg |
| Molecular Formula | C46H64O17 |
| Molecular Weight | 888.99 |
| Flash Point | 286.2±27.8 °C |
| Exact Mass | 888.414368 |
| LogP | 4.17 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.579 |
| RIDADR | NONH for all modes of transport |
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| (1S,3Z,5R,7Z,9S,11S,13S,15R,17R,21R,23R,24S,29S)-13-Acetoxy-1,11,17-trihydroxy-21-[(1R)-1-hydroxyethyl]-7-(2-methoxy-2-oxoethylidene)-2,2,12,12-tetramethyl-19,26-dioxo-20,25,30,31,32-pentaoxapentacycl ;o[21.6.1.1.1.0]dotriaconta-3,27-dien-29-yl (2E,4E)-2,4-octadienoate |