ND-654(ND654
Modify Date: 2024-01-11 12:53:20
ND-654(ND654 structure
|
Common Name | ND-654(ND654 | ||
|---|---|---|---|---|
| CAS Number | 1434641-55-0 | Molecular Weight | 583.656 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H33N3O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ND-654(ND654ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively; inhibits HepG2 cell fatty acid synthesis with an EC50 of 14 nM, and reduces both rat hepatic malonyl-CoA and rat hepatic fatty acid synthesis with ED50 values of 0.34 mg/kg and 0.30 mg/kg at Cmax, respectively; mimics the effects of ACC phosphorylation inhibits hepatic DNL and the development of HCC, selectively targets the liver and inhibits HCC proliferation, improves survival of tumor-bearing rats when used alone and in combination with the multi-kinase inhibitor sorafenib. |
| Name | ND-654 |
|---|
| Description | ND-654 (ND654) is a novel potent, liver-specific acetyl-CoA carboxylase (ACC) inhibitor with IC50 of 3/8 nM for human ACC1/ACC2, respectively; inhibits HepG2 cell fatty acid synthesis with an EC50 of 14 nM, and reduces both rat hepatic malonyl-CoA and rat hepatic fatty acid synthesis with ED50 values of 0.34 mg/kg and 0.30 mg/kg at Cmax, respectively; mimics the effects of ACC phosphorylation inhibits hepatic DNL and the development of HCC, selectively targets the liver and inhibits HCC proliferation, improves survival of tumor-bearing rats when used alone and in combination with the multi-kinase inhibitor sorafenib. |
|---|---|
| References | References 1. Lally JSV, et al. Cell Metab. 2019 Jan 8;29(1):174-182.e5. View Related Products by Target Acetyl-CoA Carboxylase (ACC) |
| Molecular Formula | C29H33N3O8S |
|---|---|
| Molecular Weight | 583.656 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: ND-654
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: ND-654 (ND654)
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
Get all suppliers and price by the below link: