SCH-42354
Modify Date: 2024-01-12 22:19:40
SCH-42354 structure
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Common Name | SCH-42354 | ||
|---|---|---|---|---|
| CAS Number | 144505-58-8 | Molecular Weight | 341.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H23NO3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SCH-42354SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2]. |
| Name | SCH-42354 |
|---|
| Description | SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2]. |
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| Related Catalog | |
| In Vitro | SCH-42354 (10-100 nM) increases the potency of natriuretic peptide (ANP) in isolated pulmonary vessels and in isolated perfused whole lungs and increases ANP activity in a dose-dependent manner[1]. |
| References |
| Molecular Formula | C16H23NO3S2 |
|---|---|
| Molecular Weight | 341.49 |