Lubeluzole

Modify Date: 2024-01-31 11:07:29

Lubeluzole Structure
Lubeluzole structure
Common Name Lubeluzole
CAS Number 144665-07-6 Molecular Weight 433.51500
Density 1.327g/cm3 Boiling Point 579.8ºC at 760mmHg
Molecular Formula C22H25F2N3O2S Melting Point N/A
MSDS N/A Flash Point 304.5ºC

 Use of Lubeluzole


Lubeluzole is a neuroprotective anti-ischemic compound. Lubeluzole, but not its (-)-R-isomer, protects against sensorimotor deficits provoked by photochemical stroke in rats. Lubeluzole inhibited glutamate-stimulated guanosine 3',5'-cyclic monophosphate production with an IC50 of 37 nM. Lubeluzole also has the potential for developing a novel class of antibacterial adjuvants endowed with spasmolytic activity[1][2].

 Names

Name (2S)-1-[4-[1,3-benzothiazol-2-yl(methyl)amino]piperidin-1-yl]-3-(3,4-difluorophenoxy)propan-2-ol
Synonym More Synonyms

 Lubeluzole Biological Activity

Description Lubeluzole is a neuroprotective anti-ischemic compound. Lubeluzole, but not its (-)-R-isomer, protects against sensorimotor deficits provoked by photochemical stroke in rats. Lubeluzole inhibited glutamate-stimulated guanosine 3',5'-cyclic monophosphate production with an IC50 of 37 nM. Lubeluzole also has the potential for developing a novel class of antibacterial adjuvants endowed with spasmolytic activity[1][2].
Related Catalog
References

[1]. Cavalluzzi MM, et al. Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies. Pharmacol Rep. 2021;73(1):172-184.

[2]. Lesage AS, et al. Lubeluzole, a novel long-term neuroprotectant, inhibits the glutamate-activated nitric oxide synthase pathway. J Pharmacol Exp Ther. 1996;279(2):759-766.

 Chemical & Physical Properties

Density 1.327g/cm3
Boiling Point 579.8ºC at 760mmHg
Molecular Formula C22H25F2N3O2S
Molecular Weight 433.51500
Flash Point 304.5ºC
Exact Mass 433.16400
PSA 77.07000
LogP 3.85290
Vapour Pressure 2.75E-14mmHg at 25°C
Index of Refraction 1.632

 Synonyms

Prosynap
Lubeluzole