NSC 668036
Modify Date: 2024-06-09 15:55:47
NSC 668036 structure
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Common Name | NSC 668036 | ||
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| CAS Number | 144678-63-7 | Molecular Weight | 460.51900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H36N2O9 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of NSC 668036NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1]. |
| Name | 9,15-diisopropyl-2,2,6,12-tetramethyl-4,7,10,13-tetraoxo-3,8,14-trioxa-5,11-diazahexadecan-16-oic acid |
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| Synonym | More Synonyms |
| Description | NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 µM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction[1]. |
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| Related Catalog | |
| In Vitro | In Xenopus, NSC668036 inhibiteds the signaling induced by Wnt3A[1]. NSC668036 (10 μM) suppresses β-catenin-driven gene transcription and abolished TGF-β1-induced migration, expression of collagen I and α-smooth muscle actin (α-SMA) in fibroblasts[2]. |
| In Vivo | In Bleomycin-induced pulmonary fibrosis murine model, NSC668036 (5 mg/kg) significantly suppresses accumulation of collagen I, α-SMA, and TGF-β1 but increased the expression of CK19, Occludin and E-cadherin that can inhibit pulmonary fibrogenesis[2]. |
| References |
| Molecular Formula | C21H36N2O9 |
|---|---|
| Molecular Weight | 460.51900 |
| Exact Mass | 460.24200 |
| PSA | 157.33000 |
| LogP | 2.40630 |
| nsc 668036 hydrate |
| NSC 668036 |