Desoxycarbadox-D3

Modify Date: 2024-01-08 00:11:46

Desoxycarbadox-D3 Structure
Desoxycarbadox-D3 structure
Common Name Desoxycarbadox-D3
CAS Number 1448350-02-4 Molecular Weight 233.241
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C11H7D3N4O2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Danger

 Use of Desoxycarbadox-D3


Desoxycarbadox-d3 is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.

 Names

Name Desoxycarbadox-D3
Synonym More Synonyms

 Desoxycarbadox-D3 Biological Activity

Description Desoxycarbadox-d3 is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

[2]. MacIntosh AI, et al. Liquid chromatographic monitoring of the depletion of carbadox and its metabolite desoxycarbadox in swine tissues. J Assoc Off Anal Chem. 1985;68(4):665-671.

[3]. Looft T, et al. Carbadox has both temporary and lasting effects on the swine gut microbiota. Front Microbiol. 2014;5:276. Published 2014 Jun 10.

[4]. Zhang K, et al. Investigation of quinocetone-induced mitochondrial damage and apoptosis in HepG2 cells and compared with its metabolites. Environ Toxicol Pharmacol. 2015;39(2):555-567.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Molecular Formula C11H7D3N4O2
Molecular Weight 233.241
Exact Mass 233.099213
LogP 1.72
Index of Refraction 1.634

 Safety Information

Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Danger
Hazard Statements H228-H302-H350
Precautionary Statements P201-P210-P308 + P313
Hazard Codes F,T
Risk Phrases R45-11-22
Safety Phrases S53-45
RIDADR UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all

 Synonyms

Hydrazinecarboxylic acid, 2-(2-quinoxalinylmethylene)-, methyl-d3 ester, (2E)-
(2H3)Methyl (2E)-2-(2-quinoxalinylmethylene)hydrazinecarboxylate