Perzinfotel
Modify Date: 2024-01-10 16:39:42
Perzinfotel structure
|
Common Name | Perzinfotel | ||
|---|---|---|---|---|
| CAS Number | 144912-63-0 | Molecular Weight | 260.18400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H13N2O5P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of PerzinfotelPerzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC50=30 nM) for the glutamate site[1][2]. |
| Name | P-[2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]-phosphonic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Perzinfotel (EAA-090) is a potent, selective, and competitive NMDA receptor antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC50=30 nM) for the glutamate site[1][2]. |
|---|---|
| Related Catalog | |
| Target |
NMDA receptor[1] |
| In Vitro | Perzinfotel blocks NMDA-induced currents with an IC50 of 0.48 μM and glutamate-induced neurotoxicity with an IC50 of 1.6 μM[1]. |
| References |
| Molecular Formula | C9H13N2O5P |
|---|---|
| Molecular Weight | 260.18400 |
| Exact Mass | 260.05600 |
| PSA | 116.75000 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264-P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
|
Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochloride).
J. Pharmacol. Exp. Ther. 310(2) , 563-70, (2004) Two novel N-methyl-d-aspartate (NMDA) antagonists with unique chemical structures, EAA-090 (2-[8,9-dioxo-2, 6-diazabicyclo[5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chlo... |
|
|
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.
Naunyn Schmiedebergs Arch. Pharmacol. 385(2) , 171-80, (2012) GluN receptors are heteromers of obligatory GluN1 subunits and GluN2(A-D) subunits. In the present study, we addressed the question whether GluN2A and GluN2B subunits play distinct roles in the format... |
| 2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-6-yl)ethylphosphonic acid |