DRP1i27
Modify Date: 2024-04-05 18:34:30
DRP1i27 structure
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Common Name | DRP1i27 | ||
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| CAS Number | 1453028-33-5 | Molecular Weight | 366.46 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H26N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DRP1i27DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1]. |
| Name | DRP1i27 |
|---|
| Description | DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1]. |
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| Related Catalog | |
| In Vitro | DRP1i27 (0-50 µM) 直接结合并抑制人 Drp1 的 GTPase 活性[1]。 DRP1i27 (0-50 µM) 能够以 Drp1 依赖性方式增加人和小鼠成纤维细胞中线粒体的细胞网络[1]。 DRP1i27 在 SPR 分析中的结合亲和力为 286 µM，在 MST 分析中的 KD 值为 190 µM[1]。 |
| References |
[1]. Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531. |
| Molecular Formula | C20H26N6O |
|---|---|
| Molecular Weight | 366.46 |