KDM2/7-IN-1

Modify Date: 2024-01-09 08:47:44

KDM2/7-IN-1 Structure
KDM2/7-IN-1 structure
Common Name KDM2/7-IN-1
CAS Number 1453071-47-0 Molecular Weight 285.37900
Density N/A Boiling Point N/A
Molecular Formula C15H27NO4 Melting Point 87 °C
MSDS N/A Flash Point N/A

 Use of KDM2/7-IN-1


KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].

 Names

Name ncdm-64
Synonym More Synonyms

 KDM2/7-IN-1 Biological Activity

Description KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1].
Related Catalog
References

[1]. Suzuki T, et al. Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56(18):7222-31.

 Chemical & Physical Properties

Melting Point 87 °C
Molecular Formula C15H27NO4
Molecular Weight 285.37900
Exact Mass 285.19400
PSA 77.84000
LogP 3.20970

 Synonyms

3-(9-cyclopropyl-N-hydroxynonanamido)propanoic acid
3-(N-hydroxy-9-cyclopropylnonanamido)propanoic acid
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