MRS 2179 tetrasodium

Modify Date: 2024-01-08 09:23:55

MRS 2179 tetrasodium Structure
MRS 2179 tetrasodium structure
Common Name MRS 2179 tetrasodium
CAS Number 1454889-37-2 Molecular Weight 513.156
Density N/A Boiling Point N/A
Molecular Formula C11H13N5O9P2Na4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MRS 2179 tetrasodium


MRS 2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM; displays no appreciable activity at P2Y2, P2Y4, or P2Y6 receptors (>30 uM); inhibits ADP-induced platelet shape change, aggregation and Ca2+ rise but has no effect on ADP-induced inhibition of adenylyl cyclase; decreases platelet count in mice.

 Names

Name Tetrasodium 9-(2-deoxy-3,5-di-O-phosphonato-α-D-erythro-pentofuranosyl)-N-methyl-9H-purin-6-amine
Synonym More Synonyms

 MRS 2179 tetrasodium Biological Activity

Description MRS 2179 is a potent, selective, competitive P2Y1 receptor antagonist with Kb of 100 nM; displays no appreciable activity at P2Y2, P2Y4, or P2Y6 receptors (>30 uM); inhibits ADP-induced platelet shape change, aggregation and Ca2+ rise but has no effect on ADP-induced inhibition of adenylyl cyclase; decreases platelet count in mice.
References References 1. Moro S, et al. J Med Chem. 1998 Apr 23;41(9):1456-66. 2. Baurand A, et al. Eur J Pharmacol. 2001 Feb 2;412(3):213-21. 3. Léon C, et al. Circulation. 2001 Feb 6;103(5):718-23. View Related Products by Target P2Y Receptor

 Chemical & Physical Properties

Molecular Formula C11H13N5O9P2Na4
Molecular Weight 513.156
Exact Mass 512.977905

 Synonyms

Tetrasodium 9-(2-deoxy-3,5-di-O-phosphonato-α-D-erythro-pentofuranosyl)-N-methyl-9H-purin-6-amine
9H-Purin-6-amine, 9-(2-deoxy-3,5-di-O-phosphono-α-D-erythro-pentofuranosyl)-N-methyl-, sodium salt (1:4)
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