Margatoxin
Margatoxin structure
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Common Name | Margatoxin | ||
|---|---|---|---|---|
| CAS Number | 145808-47-5 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C178H286N52O50S7 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of MargatoxinMargatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2]. |
| Name | Margatoxin |
|---|
| Description | Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2]. |
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| Related Catalog | |
| Target |
Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1] |
| In Vivo | Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2]. |
| References |
| Molecular Formula | C178H286N52O50S7 |
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes.
Toxicology 289(1) , 11-8, (2011) Aconitine (ACO) is a highly toxic diterpenoid alkaloid and known to exert the immunomodulatory action. However, whether it has any effects on ion currents in immune cells remains unknown. The effects ... |
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Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.
J. Phys. Chem. B 116(17) , 5132-40, (2012) The effect of the pore-blocking peptides charybdotoxin and margatoxin, both scorpion toxins, on currents through human voltage-gated hK(v)1.3 wild-type and hK(v)1.3_H399N mutant potassium channels was... |
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Contribution of Kv2.1 channels to the delayed rectifier current in freshly dispersed smooth muscle cells from rabbit urethra.
Am. J. Physiol. Cell Physiol. 301(5) , C1186-200, (2011) We have characterized the native voltage-dependent K(+) (K(v)) current in rabbit urethral smooth muscle cells (RUSMC) and compared its pharmacological and biophysical properties with K(v)2.1 and K(v)2... |
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