GJ103

Modify Date: 2024-02-05 09:18:27

GJ103 Structure
GJ103 structure
Common Name GJ103
CAS Number 1459687-89-8 Molecular Weight 342.378
Density N/A Boiling Point N/A
Molecular Formula C16H14N4O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GJ103


GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1].

 Names

Name GJ103
Synonym More Synonyms

 GJ103 Biological Activity

Description GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1].
Related Catalog
In Vivo GJ103 (10-30 μM; 4 days) 在具有纯合 TGA 突变和纯合 TAA 突变的 AT153LA 细胞中诱导 ATM 激酶活性[1]。 GJ103 在浓度高达 300 µM 时对 A-T 细胞没有表现出明显的细胞毒性[1]。
References

[1]. Du L, et, al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60.  

 Chemical & Physical Properties

Molecular Formula C16H14N4O3S
Molecular Weight 342.378
Appearance of Characters yellow

 Synonyms

2-(4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid