Fluphenazine (dihydrochloride)

Modify Date: 2024-01-04 15:26:03

Fluphenazine (dihydrochloride) structure	Common Name	Fluphenazine (dihydrochloride)
	CAS Number	146-56-5	Molecular Weight	510.44300
	Density	N/A	Boiling Point	568.3ºC at 760mmHg
	Molecular Formula	C₂₂H₂₈Cl₂F₃N₃OS	Melting Point	200-202ºC
	MSDS	Chinese USA	Flash Point	297.5ºC
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Fluphenazine (dihydrochloride)

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.

Name	2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol,dihydrochloride
Synonym	More Synonyms

Description	Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
References	[1]. Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung. 1976;26(9):1697-700. [2]. Whelpton R, Curry SH. Effect of 20, 6Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol. 1976 Dec;28(12):869-73. [3]. Javaid JI, et al. Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector. J Chromatogr Sci. 1981 Sep;19(9):439-43.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

References

[1]. Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung. 1976;26(9):1697-700.

[2]. Whelpton R, Curry SH. Effect of 20, 6Methods for study of fluphenazine kinetics in man. J Pharm Pharmacol. 1976 Dec;28(12):869-73.

[3]. Javaid JI, et al. Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen detector. J Chromatogr Sci. 1981 Sep;19(9):439-43.

Boiling Point	568.3ºC at 760mmHg
Melting Point	200-202ºC
Molecular Formula	C₂₂H₂₈Cl₂F₃N₃OS
Molecular Weight	510.44300
Flash Point	297.5ºC
Exact Mass	509.12800
PSA	55.25000
LogP	5.85290
Vapour Pressure	9.41E-14mmHg at 25°C
Storage condition	-20°C Freezer
Water Solubility	Soluble in DMSO and methanol.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL9800000

CHEMICAL NAME :: 1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-, dihydrochloride

CAS REGISTRY NUMBER :: 146-56-5

LAST UPDATED :: 199712

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C22-H26-F3-N3-O-S.2Cl-H

MOLECULAR WEIGHT :: 510.49

WISWESSER LINE NOTATION :: T C666 BN ISJ EXFFF B3- AT6N DNTJ D2Q &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2800 ug/kg/2W-C

TOXIC EFFECTS :: Musculoskeletal - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 299 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 429 ug/kg

SEX/DURATION :: male 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 92400 ug/kg

SEX/DURATION :: female 1-39 week(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - drug dependence

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :: Host-mediated assay

TEST SYSTEM :: Rodent - mouse Bacteria - Salmonella typhimurium

DOSE/DURATION :: 21250 ug/kg

REFERENCE :: IRLCDZ IRCS Medical Science: Library Compendium. (Lancaster, UK) V.3-11, 1975-83. For publisher information, see IMSCE2. Volume(issue)/page/year: 8,717,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6052 No. of Facilities: 79 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2807 (estimated) No. of Female Employees: 1490 (estimated)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H360
Precautionary Statements	P201-P301 + P310-P308 + P313
Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38
Safety Phrases	26-36/37/39-36
RIDADR	UN2811
RTECS	TL9800000
Packaging Group	III
Hazard Class	6.1
HS Code	3003909090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein.

Mol. Pharmacol. 56 , 989, (1999)

The interaction of dopaminergic antagonists with the D(1A) dopamine receptor was assessed in PC2 cells that transiently express this receptor. The maximal binding and dissociation constants for the D(...

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4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride

Fluphenazine (dihydrochloride)

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Price: $79/10mM*1mLinDMSO

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Fluphenazine (dihydrochloride)

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