Formamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

Modify Date: 2024-04-04 05:17:45

Formamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- Structure
Formamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- structure
Common Name Formamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
CAS Number 14686-61-4 Molecular Weight 399.43700
Density 1.25g/cm3 Boiling Point 705.1ºC at 760 mmHg
Molecular Formula C22H25NO6 Melting Point N/A
MSDS N/A Flash Point 380.2ºC

 Names

Name N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.25g/cm3
Boiling Point 705.1ºC at 760 mmHg
Molecular Formula C22H25NO6
Molecular Weight 399.43700
Flash Point 380.2ºC
Exact Mass 399.16800
PSA 74.30000
LogP 3.45960
Vapour Pressure 9.98E-20mmHg at 25°C
Index of Refraction 1.59

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0795000
CHEMICAL NAME :
Colchicine, N-deacetyl-N-formyl-N-methyl-
CAS REGISTRY NUMBER :
14686-61-4
BEILSTEIN REFERENCE NO. :
3179104
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H25-N-O6
MOLECULAR WEIGHT :
399.48
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JN1&VH NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
72 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

 Synthetic Route

~78%

Formamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- Structure

Formamide,N-met...

CAS#:14686-61-4

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

 Synonyms

N-Methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamid
Formamide,N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)
(-)-N-formyldemecolcine
N-methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamide
COLCHICINE,N-DEACETYL-N-FORMYL-N-METHYL
N-Formyldemeocolcine