3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride
![3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride Structure](https://image.chemsrc.com/caspic/412/147388-83-8.png)
3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride structure
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Common Name | 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 147388-83-8 | Molecular Weight | 202.68100 | |
| Density | N/A | Boiling Point | 249.2ºC at 760 mmHg | |
| Molecular Formula | C9H15ClN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 104.5ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochlorideABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2]. |
| Name | ABT-418 hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2]. |
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| Related Catalog | |
| Target |
nAChRs[1][2] |
| In Vivo | ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1]. Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1]. ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2]. ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2]. Animal Model: Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2] Dosage: 0.6 mg/kg Administration: Intraperitoneal injection; once daily; for two weeks Result: Effectively improved spatial memory. |
| References |
| Boiling Point | 249.2ºC at 760 mmHg |
|---|---|
| Molecular Formula | C9H15ClN2O |
| Molecular Weight | 202.68100 |
| Flash Point | 104.5ºC |
| Exact Mass | 202.08700 |
| PSA | 29.27000 |
| LogP | 2.48960 |
| Vapour Pressure | 0.0232mmHg at 25°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H310-H330 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| Hazard Codes | T+ |
| Risk Phrases | R26/27/28 |
| Safety Phrases | S22 |
| RIDADR | UN 2811 6.1/PG 1 |
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Alzheimer's disease therapy - an update.
Drug News Perspect. 11 , 248-55, (1998) The 5th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy focused on new therapeutic approaches for the treatment of Alzheimer 's disease (AD) based on the latest basic scien... |
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Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
J. Pharmacol. Exp. Ther. 271 , 353-61, (1994) The hydrochloride salt of (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT-418), a potent activator of select subtypes of neuronal nicotinic acetylcholine receptors enhanced retention in memory... |
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ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity.
Psychopharmacology 119 , 368-75, (1995) Previous studies have established that ABT-418 [(S)-3-methyl-5-(1 methyl-2-pyrrolidinyl)isoxazole hydrochloride] is a novel neuronal nicotinic acetylcholine receptor (nAChR) ligand with cognitive enha... |
| 3-Methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]isoxazole hydrochloride |
| 3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole,hydrochloride |