H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH

Modify Date: 2024-01-10 17:23:23

H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH Structure
H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH structure
 Common Name H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH
CAS Number 147612-86-0 Molecular Weight 1473.516
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C66H97N12O24P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH


EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].

 Names

Name L-α-Glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-leucine
Synonym More Synonyms

  Biological Activity

Description EPQpYEEIPIYL, a phosphopeptide, is a Src homology 2 (SH2) domain ligand. EPQpYEEIPIYL activates Src family members (e.g. Lck, Hck, Fyn) by binding to SH2 domains[1][2].
Related Catalog
In Vitro The hmT-derived phosphopeptide, pY324, which has the sequence EPQpYEEIPIYL, shows the highest affinity binding to GST fusion proteins of the Lck SH2 domain (5-fold higher than Lck’s affinity-for the Lck tail phosphopeptide) and the Src SH2 domain (44-fold higher than Src’s affinity for the Src tail phosphopeptide)[1].
References

[1]. G Payne, et al. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct;1(2):99-105.

[2]. T D Mulhern, et al. The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificity. Structure. 1997 Oct 15;5(10):1313-23.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C66H97N12O24P
Molecular Weight 1473.516
Exact Mass 1472.647583
LogP 1.01
Index of Refraction 1.586

 Synonyms

L-α-Glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl-L-leucine
L-Leucine, L-α-glutamyl-L-prolyl-L-glutaminyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-prolyl-L-isoleucyl-L-tyrosyl-
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Chemsrc provides CAS#:147612-86-0 MSDS, density, melting point, boiling point, structure, etc. Its name is H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH>> amp version: H-Glu-Pro-Gln-Tyr(PO3H2)-Glu-Glu-Ile-Pro-Ile-Tyr-Leu-OH

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