ω-Conotoxin MVIIC

Modify Date: 2024-01-01 22:42:59

ω-Conotoxin MVIIC Structure
ω-Conotoxin MVIIC structure
Common Name ω-Conotoxin MVIIC
CAS Number 147794-23-8 Molecular Weight 2749.251
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C106H178N40O32S7 Melting Point N/A
MSDS USA Flash Point N/A

 Use of ω-Conotoxin MVIIC


ω-Conotoxin MVIIC is a N- and P/Q-type Ca2+ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release[1].

 Names

Name {(1R,4S,7S,10S,13S,16S,19S,22R,27R,30S,36S,39S,45R,48S,54S,57R,62R,65S,71S,77S,83S)-62-Amino-7,30,65,71-tetrakis(4-aminobutyl)-4,36,39-tris(3-carbamimidamidopropyl)-27-carbamoyl-16-(4-hydroxybenzyl)-10-(1-hydroxyethyl)-48,54-bis(hydroxymethyl)-77-methyl-13-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,17,20,29,32,35,38,41,44,47,50,53,56,63,66,69,72,75,78,84,91-pentacosaoxo-24,25,59,60,87,88-hexathia-3,6,9,12,15,18,21,28,31,34,37,40,43,46,49,52,55,6$CYS-LYS-GLY-LYS-GLY-ALA-PRO-CYS-ARG-LYS-THR-MET-TYR-ASP-CYS-CYS-SER-GLY-SER-CYS-GLY-ARG-ARG-GLY-LYS-CYS-NH2
Synonym More Synonyms

 ω-Conotoxin MVIIC Biological Activity

Description ω-Conotoxin MVIIC is a N- and P/Q-type Ca2+ channel blocker, significantly suppresses the 11-keto-βboswellic acid-mediated inhibition of glutamate release[1].
Related Catalog
References

[1]. Cheng Wei Lu, et al. 11-Keto-β-Boswellic Acid Attenuates Glutamate Release and Kainic Acid-Induced Excitotoxicity in the Rat Hippocampus. Planta Med. 2020 Apr;86(6):434-441.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C106H178N40O32S7
Molecular Weight 2749.251
Exact Mass 2747.157471
PSA 1372.92000
LogP -20.33
Index of Refraction 1.723

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR UN 3172
Packaging Group III
Hazard Class 6.1(b)

 Articles28

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Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow.

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Spinal afferent neurons, with endings in the intestinal mesenteries, have been shown to respond to changes in vascular perfusion rates. The mechanisms underlying this sensitivity were investigated in ...

Glutamate regulates neurite outgrowth of cultured descending brain neurons from larval lamprey.

Dev. Neurobiol. 67(2) , 173-88, (2007)

In larval lamprey, descending brain neurons, which regenerate their axons following spinal cord injury, were isolated and examined in cell culture to identify some of the factors that regulate neurite...

Effects of Ca2+ channel antagonists on acetylcholine and catecholamine releases in the in vivo rat adrenal medulla.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 287(1) , R161-6, (2004)

To elucidate the types of voltage-dependent Ca(2+) channels controlling ACh and catecholamine releases in the in vivo adrenal medulla, we implanted microdialysis probes in the left adrenal medulla of ...

 Synonyms

CTX MVIIC
conotoxin MVIIC
omega-Conotoxin M VIIC
{(1R,4S,7S,10S,13S,16S,19S,22R,27R,30S,36S,39S,45R,48S,54S,57R,62R,65S,71S,77S,83S)-62-Amino-7,30,65,71-tetrakis(4-aminobutyl)-4,36,39-tris(3-carbamimidamidopropyl)-27-carbamoyl-16-(4-hydroxybenzyl)-10-(1-hydroxyethyl)-48,54-bis(hydroxymethyl)-77-methyl-13-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,17,20,29,32,35,38,41,44,47,50,53,56,63,66,69,72,75,78,84,91-pentacosaoxo-24,25,59,60,87,88-hexathia-3,6,9,12,15,18,21,28,31,34,37,40,43,46,49,52,55,6
Snx 230
conotoxin MVIIC_smartox
{(1R,4S,7S,13S,16S,19S,22R,27R,30S,36S,39S,45R,48S,54S,57R,62R,65S,71S,77S,83S)-62-Amino-7,30,65,71-tetrakis(4-aminobutyl)-4,36,39-tris(3-carbamimidamidopropyl)-27-carbamoyl-16-(4-hydroxybenzyl)-10-[(1R)-1-hydroxyethyl]-48,54-bis(hydroxymethyl)-77-methyl-13-[2-(methylsulfanyl)ethyl]-2,5,8,11,14,17,20,29,32,35,38,41,44,47,50,53,56,63,66,69,72,75,78,84,91-pentacosaoxo-24,25,59,60,87,88-hexathia-3,6,9,12,15,18,21,28,31,34,37,40,43,46,49,52,55,
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