5β-Dihydrocortisol

Modify Date: 2024-01-09 10:16:10

5β-Dihydrocortisol structure	Common Name	5β-Dihydrocortisol
	CAS Number	1482-50-4	Molecular Weight	364.47600
	Density	1.249g/cm3	Boiling Point	544.5ºC at 760mmHg
	Molecular Formula	C₂₁H₃₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	297.1ºC

Use of 5β-Dihydrocortisol

5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].

Name	(8S,9S,10S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
Synonym	More Synonyms

Description	5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	5β-Dihydrocortisol (10-100 μM; 48 h) inhibits the viability of MCF-7 cells, with an IC50 of 27.59 μM[2]. 5β-Dihydrocortisol (14 μM; 24 h) induces 35.6% early apoptosis and 2.5% late apoptosis in MCF-7 cells[2]. 5β-Dihydrocortisol (1-10 μM; 48 h) quenches the intrinsic fluorescence of human serum albumin (HAS) with a maximum emission peak at 360 nm, with no shift in fluorescence peak[2]. Cell Viability Assay[2] Cell Line: MCF-7 and HEK 293 cells Concentration: 10, 20, 40, 60, 80, 100 μM Incubation Time: 48 hours Result: Inhibited the viability of MCF-7 cells in a dose-dependent manner. No toxicity in terms of cell viability was observed with HEK293 cell line. Apoptosis Analysis[2] Cell Line: MCF-7 cells Concentration: 14 μM Incubation Time: 24 hours Result: Induced 35.6% and 2.5% of early and late apoptosis.
In Vivo	5β-Dihydrocortisol (0.1-1.0%; 18 d) potentiates the action of topically applied Dexamethasone (0.06%) in raising the intraocular pressure (IOP) in young rabbits[3].
References	[1]. Marver D, et, al. Dihydrocortisol: a potential mineralocorticoid. J Steroid Biochem. 1978 Jan;9(1):1-7. [2]. Kallubai M, et, al. Spectroscopic evaluation of synthesized 5β-dihydrocortisol and 5β-dihydrocortisol acetate binding mechanism with human serum albumin and their role in anticancer activity. J Biomol Struct Dyn. 2019 Feb;37(3):623-640. [3]. Southren AL, et, al. 5 beta-Dihydrocortisol: possible mediator of the ocular hypertension in glaucoma. Invest Ophthalmol Vis Sci. 1985 Mar;26(3):393-5. [4]. Appanna N, et, al. Differential activity and expression of human 5β-reductase (AKR1D1) splice variants. J Mol Endocrinol. 2021 Mar;66(3):181-194. [5]. Weinstein BI, et, al. Potentiation of glucocorticoid activity by 5 beta-dihydrocortisol: its role in glaucoma. Science. 1983 Oct 14;222(4620):172-3.

Density	1.249g/cm3
Boiling Point	544.5ºC at 760mmHg
Molecular Formula	C₂₁H₃₂O₅
Molecular Weight	364.47600
Flash Point	297.1ºC
Exact Mass	364.22500
PSA	94.83000
LogP	1.86150
Index of Refraction	1.569

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU4158700

CHEMICAL NAME :: 5-beta-Pregnane-3,20-dione, 11-beta,17,21-trihydroxy-

CAS REGISTRY NUMBER :: 1482-50-4

LAST UPDATED :: 199712

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H32-O5

MOLECULAR WEIGHT :: 364.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Human Liver

DOSE/DURATION :: 2 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 370,49,1996

5B-Dihydrocortisol

hydrocortison

5B-pregnane-11B-17A-21-triol-3-20-dione

5BETA-PREGNAN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE

dihydrocortisol

5β-Dihydrocortisol

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 5β-Dihydrocortisol
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Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 5β-Dihydrocortisol
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pregnane-3,20-dione,11,17,21-trihydroxy-, (5b,11b)-
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Purity: 98.0%
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Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥3080/10 mM * 1 mL in DMSO

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5β-Dihydrocortisol

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