Ivabradine hydrochloride

Modify Date: 2024-01-02 20:00:28

Ivabradine hydrochloride structure	Common Name	Ivabradine hydrochloride
	CAS Number	148849-67-6	Molecular Weight	505.046
	Density	N/A	Boiling Point	626.9ºC at 760mmHg
	Molecular Formula	C₂₇H₃₇ClN₂O₅	Melting Point	193-196?C
	MSDS	Chinese USA	Flash Point	332.9ºC
	Symbol	GHS09	Signal Word	Warning

Use of Ivabradine hydrochloride

Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.

Name	ivabradine hydrochloride
Synonym	More Synonyms

Description	Ivabradine (hydrochloride) is a new If inhibitor with IC50 of 2.9 μM, and used as a pure heart rate lowering agent.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease
In Vivo	Ivabradine treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression[1]. Ivabradine leads to a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension[2].
References	[1]. Fang, Y., et al. Heart rate reduction induced by the if current inhibitor ivabradine improves diastolic function and attenuates cardiac tissue hypoxia. J Cardiovasc Pharmacol, 2012. 59(3): p. 260-7. [2]. Kroller-Schon, S., et al. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress. Basic Res Cardiol, 2011. 106(6): p. 1147-58.

Boiling Point	626.9ºC at 760mmHg
Melting Point	193-196?C
Molecular Formula	C₂₇H₃₇ClN₂O₅
Molecular Weight	505.046
Flash Point	332.9ºC
Exact Mass	504.239105
PSA	60.47000
LogP	4.04990
Vapour Pressure	1.24E-15mmHg at 25°C
Storage condition	-20°C Freezer

Ivabradine hydrochloride MSDS(Chinese)

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H400
Precautionary Statements	P273
Hazard Codes	N
Risk Phrases	50/53
Safety Phrases	60-61
RIDADR	UN 3077 9 / PGIII

Precursor 9
CAS#:1086026-31-4 3-[3-[[[(7S)-3,... CAS#:155974-00-8 Ivabradine CAS#:20925-64-8 7,8-Dimethoxy-1... CAS#:1031767-71-1 3-chloro-N-{[(7...
CAS#:35202-54-1 4,5-Dimethoxy-1... CAS#:41234-23-5 4,5-Dimethoxybe... CAS#:35249-62-8 3-(2-Bromo-4,5-... CAS#:866783-12-2 (S)-(4,5-dimeth...
CAS#:85175-65-1 2H-3-Benzazepin...
DownStream 1
CAS#:155974-00-8 Ivabradine

Beat Rate Variability in Murine Embryonic Stem Cell-Derived Cardiomyocytes: Effect of Antiarrhythmic Drugs.

Cell Physiol. Biochem. 38 , 646-58, (2016)

Heart rate variability (HRV) refers to the fluctuation of the time interval between consecutive heartbeats in humans. It has recently been discovered that cardiomyocytes derived from human embryonic a...

Ivabradine hydrochloride

AMG 998

Coralan

Procoralan

Corlentor

3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one,hydrochloride

ivabradine monohydrochloride

2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride

Ivabradine hcl

2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-, hydrochloride (1:1)

MFCD00929899

3-{3-[{[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride (1:1)

UNII-TP19837BZK

Corlanor