Procyclidine hydrochloride
Modify Date: 2024-01-06 13:56:55
Procyclidine hydrochloride structure
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Common Name | Procyclidine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1508-76-5 | Molecular Weight | 323.90100 | |
| Density | N/A | Boiling Point | 433.5ºC at 760 mmHg | |
| Molecular Formula | C19H30ClNO | Melting Point | 85.5 to 86.5ºC | |
| MSDS | USA | Flash Point | 205.7ºC | |
Use of Procyclidine hydrochlorideProcyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties. |
| Name | procyclidine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Procyclidine hydrochloride is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties. |
|---|---|
| Related Catalog | |
| Target |
NMDA Receptor[1] |
| In Vivo | Procyclidine widely used as anti-parkinsonian agents because of their anti-cholinergic action, is also known to have NMDA antagonist properties. Unlike other NMDA antagonists, these agents-because of their anti-cholinergic action-are devoid of neurotoxic side effects. Procyclidine alleviates thermal hyperalgesia in a dose dependent manner; when a marginally effective dose of the agent is combined with an ineffective dose of an alpha(2) adrenergic agonist (Clonidine or Guanabenz), the combination therapy provides effective and long-lasting relief from neuropathic pain[1]. |
| Animal Admin | Rats[1] Adult Sprague-Dawley female rats (weight 300-330 g) are used. Procyclidine given systemically causes a transient increase in locomotor activity (mainly non-ambulatory fine movements) in adult rats. Locomotor activity data (ambulations, fine movements) are evaluated using a two-way ANOVA to test whether co-administration of clonidine (0.025 mg/kg) with various doses of Procyclidine (10, 25, 50 and 75 mg/kg) altered the activity levels compared to the same doses of Procyclidine administered alone. A one-way ANOVA and subsequent comparisons are also conducted to establish whether the activity levels for each treatment group are different from saline controls. |
| References |
| Boiling Point | 433.5ºC at 760 mmHg |
|---|---|
| Melting Point | 85.5 to 86.5ºC |
| Molecular Formula | C19H30ClNO |
| Molecular Weight | 323.90100 |
| Flash Point | 205.7ºC |
| Exact Mass | 323.20200 |
| PSA | 23.47000 |
| LogP | 4.68030 |
| Vapour Pressure | 2.76E-08mmHg at 25°C |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R20/21/22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UY1926000 |
| HS Code | 2933990090 |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Procyclidine hydrochloride |
| Procyclidine Hydrochloride |
| PROCYCLIDINE HYDROCHLORIDE |