Pramlintide

Modify Date: 2024-01-04 11:22:17

Pramlintide Structure
Pramlintide structure
Common Name Pramlintide
CAS Number 151126-32-8 Molecular Weight 3949.43
Density N/A Boiling Point N/A
Molecular Formula C171H269N51O53S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pramlintide


Pramlintide is a polypeptide analogue of human amylin. Pramlintide is an antidiabetic, is antineoplastic in colorectal cancer[1].

 Names

Name Pramlintide
Synonym More Synonyms

 Pramlintide Biological Activity

Description Pramlintide is a polypeptide analogue of human amylin. Pramlintide is an antidiabetic, is antineoplastic in colorectal cancer[1].
Related Catalog
In Vitro Pramlintide inhibits the growth of HCT-116 and HT-29 in a dose-dependent manner, with higher efficacy against the latter (IC50s of 48.67 and 9.10 μg/mL, respectively)[1]. The addition of 5, 10, and 20 μg/mL of Pramlintide to HCT-116 and HT-29 with 5-fluorouracil, Oxaliplatin, or Irinotecan induces the antiproliferative effect synergistically[1].
References

[1]. Maha S Al-Keilani, et al. Pramlintide, an antidiabetic, is antineoplastic in colorectal cancer and synergizes with conventional chemotherapy. Clin Pharmacol. 2018 Mar 5;10:23-29.

 Chemical & Physical Properties

Molecular Formula C171H269N51O53S2
Molecular Weight 3949.43
Storage condition -20℃

 Synonyms

Triproamylin